Phagocytic activity of neuronal progenitors regulates adult neurogenesis
نویسندگان
چکیده
منابع مشابه
Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis.
D-aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L-aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic develo...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2011
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb2299